8月24日,中山大學(xué)潘志忠,林俊忠和彭健宏共同通訊在《Autophagy》在線(xiàn)發(fā)表題為“Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer”的研究論文,該研究發(fā)現(xiàn)CRC腫瘤環(huán)境中積累了乳酸,并充當(dāng)了組蛋白乳?;牡孜?,這一過(guò)程在缺氧條件下通過(guò)細(xì)胞增強(qiáng)的糖酵解進(jìn)一步誘導(dǎo)。