研究揭示個(gè)體對(duì)疫苗反應(yīng)差異的原因
2020-02-26
來(lái)源：小柯機(jī)器人
美國(guó)國(guó)立衛(wèi)生研究院John S. Tsang研究組近日取得一項(xiàng)新成果。他們發(fā)現(xiàn)健康個(gè)體對(duì)疫苗的反應(yīng)與系統(tǒng)性狼瘡患者病理表現(xiàn)的共有特征基礎(chǔ)是廣泛的免疫激活。2020年2月24日，國(guó)際學(xué)術(shù)期刊《自然—醫(yī)學(xué)》在線發(fā)表了這一成果。
研究人員揭示了基線血液轉(zhuǎn)錄特征，其可預(yù)測(cè)健康受試者對(duì)流感和黃熱病疫苗的抗體反應(yīng)。對(duì)這些相同特征的臨床靜止期評(píng)估發(fā)現(xiàn)，其與系統(tǒng)性紅斑狼瘡伴漿母細(xì)胞相關(guān)性耀斑患者的病理特征相關(guān)。
對(duì)流感疫苗免疫應(yīng)答高或低的健康人的82種表面蛋白和53,201個(gè)單細(xì)胞轉(zhuǎn)錄組CITE-seq分析顯示，該特征反映了漿細(xì)胞樣樹突狀細(xì)胞I型IFN-T / B淋巴細(xì)胞網(wǎng)絡(luò)中的活化程度。該發(fā)現(xiàn)揭示了調(diào)節(jié)此類免疫基線可以改善疫苗反應(yīng)性并減輕不良自身免疫反應(yīng)。
研究人員表示，個(gè)體對(duì)疫苗接種和疾病的反應(yīng)差異很大，這可能部分是由于基線免疫變異所致。免疫應(yīng)答的基線預(yù)測(cè)因子及其生物學(xué)基礎(chǔ)對(duì)于癌癥免疫治療、疾病診治、疫苗接種和感染應(yīng)答的潛在重要性具有廣泛的意義。
附：英文原文
Title: Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus
Author: Yuri Kotliarov, Rachel Sparks, Andrew J. Martins, Matthew P. Mul, Yong Lu, Meghali Goswami, Lela Kardava, Romain Banchereau, Virginia Pascual, Anglique Biancotto, Jinguo Chen, Pamela L. Schwartzberg, Neha Bansal, Candace C. Liu, Foo Cheung, Susan Moir, John S. Tsang
Issue&Volume: 2020-02-24
Abstract: Responses to vaccination and to diseases vary widely across individuals, which may be partly due to baseline immune variations. Identifying such baseline predictors of immune responses and their biological basis is of broad interest, given their potential importance for cancer immunotherapy, disease outcomes, vaccination and infection responses. Here we uncover baseline blood transcriptional signatures predictive of antibody responses to both influenza and yellow fever vaccinations in healthy subjects. These same signatures evaluated at clinical quiescence are correlated with disease activity in patients with systemic lupus erythematosus with plasmablast-associated flares. CITE-seq profiling of 82 surface proteins and transcriptomes of 53,201 single cells from healthy high and low influenza vaccination responders revealed that our signatures reflect the extent of activation in a plasmacytoid dendritic cell–typeI IFN–T/B lymphocyte network. Our findings raise the prospect that modulating such immune baseline states may improve vaccine responsiveness and mitigate undesirable autoimmune disease activity.
DOI: 10.1038/s41591-020-0769-8
Source: https://www.nature.com/articles/s41591-020-0769-8
聲明：本文版權(quán)歸原作者所有，轉(zhuǎn)載文章僅為傳播更多信息，如作者信息標(biāo)記有誤，或侵犯您的版權(quán)，請(qǐng)聯(lián)系我們，我們將在及時(shí)修改或刪除內(nèi)容，聯(lián)系郵箱：marketing@360worldcare.com
